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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Chem Rev. 2020 Dec 23;121(18):10908–10949. doi: 10.1021/acs.chemrev.0c00923

Figure 5. Crosslinking via thiol-ene Michael addition.

Figure 5.

a) Schematic representation of methacrylate-modified biopolymers (black) crosslinked with a dithiol crosslinker (blue) under Michael addition conditions. b) Schematic representation of a biopolymer modified with multiple ene groups that can undergo thiol-ene Michael addition. From left to right, in decreasing order of Michael addition reactivity: maleimide, vinyl sulfone, acrylate, and methacrylate. c) Thiolated heparin is crosslinked with diacrylated PEG (PEGDA) via a thiol-ene Michael addition reaction, which was used for the culture of primary rat hepatocytes and hepatocyte growth factor (HGF). Adapted with permission from Kim, et al.205 Copyright, 2010 Elsevier.