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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Chem Rev. 2020 Dec 23;121(18):10908–10949. doi: 10.1021/acs.chemrev.0c00923

Figure 9. Crosslinking via catechol reactions.

Figure 9.

a) Schematic representation of biopolymers modified with catechol and crosslinking in the presence of NaIO4 to form dicatechol adducts. b) A mussel-inspired, HA hydrogel is formed by modifying HA with catechol moieties (HA-CA). HA-CA is covalently crosslinked in the presence of sodium periodate (NaIO4). Image shows HA-CA hydrogel before (clear) and after (red) gelation. Adapted with permission from Shin, et al.251 Copyright, 2015 Wiley.