Table 1.

Causes of acquired FXIII deficiency.

Adapted from Yan et al. [17]

	Pathophysiology	Associated conditions
Immune	Autoantibody-mediated inhibition or rapid clearance	Autoimmune disease  Systemic lupus erythematosus (SLE)  Rheumatoid arthritis Malignancy  Solid tumours  Haematologic malignancy Medications  Isoniazid Monoclonal gammopathy of undetermined significance (MGUS)
Non-immune	Hyper-consumption	Surgery Disseminated intravascular coagulation (DIC) Inflammatory bowel disease Henoch-Schoenlein purpura (HSP) Sepsis Thrombosis Pulmonary embolism, stroke
	Hypo-synthesis	Liver disease Leukaemia Medications  Valproate  Tocilizumab