TABLE 3.

AUC and AUC/MIC ratio for total LY and free LY

Dose (mg/kg)	Mean AUC0–24 (μg · h/ml) for total drug	AUC/MIC for total drug	AUC (μg · h/ml) for free drug corrected for 75% plasma protein binding	AUC/MIC for free drug assuming 75% plasma protein binding	AUC for free drug corrected for 95% plasma protein binding	AUC/MIC ratio for free drug assuming 95% plasma protein binding
0.1	0.565	37.6	0.141	2	0.03	0.5
0.25	1.56	104	0.39	26	0.08	5.3
0.5	3.47	231	0.87	58	0.17	11.3
1.0	10.06	671	2.5	167	0.50	33.3