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. 2022 Feb 15;121(6):886–896. doi: 10.1016/j.bpj.2022.02.018

Figure 3.

Figure 3

SFA analysis of CL-induced hemifusion contacts formation on PSM model (DPPC:DOPG 3:1 mol % with [diseased] and without [healthy] CL) mica-SLBs in water at room temperature. (A) Long-range force (F) versus (D). Lines are fits of Eq. S3 to experimental data (red-orange for inter-bilayer forces and blue for inter-vesicles forces). (B) Short-range inter-bilayer forces; line is the fit of Eq. 1 to experiment. (C) Schematic of the PSM model highlighting two juxtaposed monolayers that join through hemifusion mediated by inverted-conical CL molecules. (D) Force profile during separation (jump out) of bilayer leaflets. (E) Time-resolved hemifusion (jump in) at an applied compression of 60 nN. To see this figure in color, go online.