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. 2022 Feb 15;121(6):886–896. doi: 10.1016/j.bpj.2022.02.018

Figure 4.

Figure 4

Laser scanning confocal microscopy images of bovine PSM extract GMLVs tagged with 0.1 mol % of 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate. (A) A large healthy bovine PSM extract GMLV with discrete lamellae is visible, with a denser GMLV in the top left. The region highlighted by a dashed white box is magnified on the right at three time points. The lamellae undulate to maintain a stable inter-bilayer separation. Horizontal arrows point to horizontal jogs that are motion artifacts. (B) A large diseased bovine PSM extract GMLV with discrete lamellae is visible. Lamellae appear to be grouped in pairs but with intermembrane contacts (yellow arrows) that are stable for at least 10 s. Several bilayer pairs are highlighted with thick yellow lines. All images have the same 5 μm scale. To see this figure in color, go online.