Table 3.

Association between patient characteristics and incidence of first HBsAg loss expressed as rate ratios (RRs)¹

	N	Unadjusted RR (95% CI)	P Value	N	Adjusted RR (95% CI)2	P value
Baseline Characteristics
Age, years (ref>=60)	1240		0.01
<18		0.41 (0.14, 1.16)
18 to <30		0.06 (0.01, 0.45)
30-<50		0.47 (0.28, 0.79)
50-<60		0.71 (0.40, 1.24)
Female sex	1240	0.67 (0.45, 1.02)	0.06
Asian (Ref: Non-Asian) 3	1203	0.63 (0.41, 0.95)	0.03
Phenotype (Ref: Inactive carrier)	1176		<0.001	1143		<0.001
HBeAg- CHB		0.22 (0.11, 0.44)			0.24 (0.12, 0.49)
Indeterminant		0.43 (0.27, 0.66)			0.44 (0.28, 0.69)
Non-A Genotype 4	1055	0.72 (0.41, 1.27)	0.26	1055	0.77 (0.43, 1.35)	0.36
BCP/PC mutation (Ref: wild type)	628		0.07	609		0.11
BCP only		0.41 (0.15, 1.11)			0.42 (0.15, 1.16)
PC only		0.27 (0.09, 0.81)			0.29 (0.10, 0.87)
BCP & PC		0.72 (0.30, 1.76)			0.63 (0.23, 1.74)
Time-Varying Variables
HBV treatment (≥24 wks in past 36 wks)	1240	0.34 (0.14, 0.84)	0.02
Quantitative HBsAg per 1 log10 IU/mL increase	1219	0.25 (0.18, 0.35)	0.001	1182	0.24 (0.18, 0.32)	<0.001
HBV DNA per 1 log10 IU/mL increase	1240	0.35 (0.28, 0.43)	<0.001	1203	0.22 (0.16, 0.30)	<0.001
ALT per 1x ULN increase	1234	0.56 (0.31, 1.02)	0.06	1197	0.63 (0.36, 1.11)	0.11
Platelet per 103/mm3 increase	1185	1.002 (0.998, 1.01)	0.03	1150	1.003 (0.999, 1.01)	0.11

¹The ratio of the rate at which participants experienced HBsAg loss where a lower rate suggests a longer time to HBsAg negative. Thus, a value <1 indicates longer time to HBsAg loss.

²Each estimate is from a unique model adjusting for age group, sex, race, and treatment with one exception; genotype is not adjusted for race. For adjusted model, age was regrouped to combine all <30 in one group because of lack of HBsAg loss in lower age groups [Supplemental sTable 1].

³Does not include “Other/Mixed” race (n=33).

⁴Does not include “Other (E, F, and multiple)” genotype (n=41).