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. 2022 Mar 22;219(5):e20200795. doi: 10.1084/jem.20200795

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© 2022 Kim et al.

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Figure 4. — Dynamic expression of CD25 on TRCs during EAE induction. (A) The overall scheme and severity of EAE induction (n ≥ 10 per each group). (B) The expression of CD25 on CD31⁻gp38⁺ gated TRC population from normal (black lines) or EAE-induced (red lines) freshly isolated iLNs is shown by flow cytometric histograms at the designated time points. Gray histograms represent isotype control. (C) The frequency of IL-17A–producing CD4⁺ T cells in iLN, as detected by flow cytometry at the indicated time points. (D) Compiled data show the kinetics of IL-17A⁺CD4⁺ T cells and CD25⁺ TRCs in iLN during EAE induction. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with day 0 results. Error bars indicate the mean ± SEM (n = 4 per each group). Data are representative of three independent experiments.