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. 2022 Mar 22;219(5):e20200795. doi: 10.1084/jem.20200795

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© 2022 Kim et al.

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Figure 6. — CD25^fl/flCCL19^cre mice exhibit more severe EAE and higher Th17 cell differentiation vs. controls. (A) EAE was induced in CCL19^cre and CD25^fl/flCCL19^cre mice, and disease severity was measured. *, P < 0.05; ***, P < 0.001 compared with EAE-induced CCL19^cre mice (n = 6 per each group). (B) EAE incidence was assessed for the indicated length of time. (C–E) Inflammatory cells were extracted from CNS-infiltrating (C), iLNs (D), and spleens (E) of EAE-induced mice and analyzed for cytokine production. *, P < 0.05; **, P < 0.01 compared with the EAE-induced CCL19^cre mice. Error bars indicate the mean ± SEM. Data are representative of three independent experiments.