Substrate scope of the aldol addition reactions catalyzed by CPOC-302-Pro^a.

^aReaction conditions: aldehyde (0.20 mmol), ketone (2.0 mmol), 10 mol% catalyst (relative to the quantity of proline in the material), 4-NBA (20 mol%), H₂O (0.01 mL), and MTBE (1.0 mL) at r.t. for 3 days. Isolated yield. The above catalytic products were characterized by ¹H NMR and their ee values were determined by chiral HPLC.

^bUnder the 0 °C reaction conditions.