Table 3.
Comparison of outcomes between spectrum in appropriate antibiotics and inappropriate spectrum antibiotics groups
| Appropriate antibiotics spectrum, N=489 | Inappropriate antibiotics spectrum, N=104 | Adjusted odds ratioa Adjusted coefficientb: Appropriate antibiotics |
P value | |
|---|---|---|---|---|
| 28-day mortality, n (%) | 14 (2.9%) | 9 (8.78%) | 0.38 (0.15, 0.99) a | 0.047 |
| In-hospital mortality, n (%) | 21 (4.3%) | 15 (14.4%) | 0.28 (0.13, 0.61) a | 0.001 |
| 28-day ventilator- free days, mean ± SD | 26.77±4.46 | 23.75±8.73 | 0.06** (0.01, 0.11) b | 0.01 |
| 28-day hospital-free days, mean ± SD | 21.27±8.08 | 16.90±10.48 | 0.10** (− 0.00, 0.21) b | 0.06 |
aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
bApply log transformation for fitting model to normal distribution before adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 16 data of 28-day ventilator free day and 57 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 577 patients for 28-day ventilator free day and 536 patients 28-day hospital free day outcomes
SD standard deviation, qSOFA quick Sequential Organ Failure Assessment