Table 4.
Comparison of primary and secondary outcomes between appropriate antibiotics and inappropriate antibiotics groups in subgroup patients who had SOFA ≥ 2
| Outcomes | Appropriate antibiotics N=155 |
Inappropriate antibiotics N=115 |
Adjusted odds ratioa Adjusted coefficientb: Appropriate antibiotics |
P value |
|---|---|---|---|---|
| Primary outcomes | ||||
| 28-day mortality, n (%) | 9 (5.81%) | 9 (7.83%) | 0.60 (0.19, 1.77) a | 0.35 |
| In-hospital mortality, n (%) | 59 (9.68%) | 14 (12.17%) | 0.68 (0.29, 1.60) a | 0.38 |
| 28-day ventilator- free days, mean ± SD | 25.35±6.70 | 25.36±7.04 | − 0.01 (− 0.09, 0.06) b | 0.71 |
| 28-day hospital-free days, mean ± SD | 18.96±8.94 | 17.95±9.84 | 0.08 (− 0.05, 0.22) b | 0.21 |
aAdjusted odds ratio (95% confidence interval): qSOFA, respiratory rate, oxygen saturation
bApply log transformation for the fitting model to normal distribution before Adjusted coefficient (mean difference): qSOFA, respiratory rate, oxygen saturation. After we did a log transform, 12 data of 28-day ventilator-free day and 36 data of 28-day hospital free day were missing because log [0] transformed to infinities. We had completed case analysis as 258 patients for 28-day ventilator-free day and 234 patients 28-day hospital-free day outcomes
SD standard deviation, qSOFA quick Sequential Organ Failure Assessment, SOFA Sequential Organ Failure Assessment