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. 2022 Mar 24;21:106. doi: 10.1186/s12936-021-03980-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Observed time-to-recrudescence for ACT stratified by region and duration of follow-up. The y-axis depicts the time for the recrudescent infection to reach microscopic limit of detection (50 parasites/µL). In Africa, the distribution is shown for children < 5 years age, whereas in Asia/ S. America, data are shown for patients of all ages. Each dot represents an observed recrudescence. AL = artemether-lumefantrine; DP = dihydroartemisinin-piperaquine; ASMQ = artesunate-mefloquine; ASAQ = artesunate-amodiaquine, and n = number of recrudescences. Only data from studies with at least three molecular markers are shown in the graph. For DP (Asia), the graph depicts recrudescences observed in studies from Asia and S. America combined