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. 2022 Mar 24;21:106. doi: 10.1186/s12936-021-03980-z

Fig. 3.

Fig. 3

Fractional polynomial estimates of cumulative and instantaneous hazard for AL and DP. The cumulative baseline hazard estimated from Cox model (adjusted for age, baseline parasitaemia and mg/kg dosage of partner drug) together with fractional polynomial smoother (left panel). The temporal trend of observing recrudescence during the follow-up period, estimated by the instantaneous baseline hazard function (right panel). Data in Africa was restricted to children < 5 years whereas patients of all ages were included in Asia and S. America. Data from S. America were grouped with Asia. All studies used at least 3 locus genotypes (the usage of microsatellites was considered as a separate locus). Under-dosed was defined as total piperaquine dose ≤ 48 mg/kg (those receiving > 48 mg/kg defined as not under-dosed). AL = artemether-lumefantrine; DP = dihydroartemisinin-piperaquine. The equations for the cumulative baseline hazard functions derived using the fractional polynomial smoothing are presented in the Additional file 1