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. 2022 Mar 24;20:37. doi: 10.1186/s12964-022-00847-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Tumor growth inhibition by CPX in an NSCLC mouse xenograft model. A–D Tumor-bearing nude mice (6 mice per group) were injected intraperitoneally with either CPX (20 mg/kg) or 0.9% NaCl, respectively. Data were presented as mean ± SD (n = 6, ***for p < 0.001, ns: no significance for indicated comparison). Tumor volumes evaluated (A) after 14 days of continuous injection, the images of dissected tumors from tumor-bearing mice were shown (B) and the tumor weight was measured (C). Changes in the mean body weight in the two groups of CPX or 0.9% NaCl injection xenograft model (D). E and F Representative images of IHC staining of Ki67, Cleaved-Caspase 3, and Tunel in the tumor of NSCLC mouse xenograft model injected intraperitoneally with 0.9% NaCl or CPX (20 mg/kg) (E), and Ki67, Cleaved-Caspase 3 and TUNEL-positive staining cells in the tumor sections were quantified by ImageJ Plus (F). Data were presented as mean ± SD (n = 6; ***for p < 0.001; ns = not significant)