Table 5.
The most relevant hyper- and hypomethylated genes in HCC
| Genes | DNA Methylation pattern in HCC |
Reference |
|---|---|---|
| HHIP, PTGR1, TMEM106A, MT1M, MT1E, CPS1, CDKN2A | Hyper | [16] |
| CDKN2A, MLH1, FZD7, SOCS1, APC, RASSF1 | Hyper | [107] |
| HIST1H2AJ, SPDYA | Hyper | [108] |
| HRNBP3 | Hypo | |
| CDKN2A | Hyper | [113] |
| FZD7, CDKN2A, APC, RASSF1 | Hyper | [114] |
| SOCS1, RASSF1 | Hyper | [115] |
| CHFR, MGMT, RASSF1, GSTP1 | Hyper | [116] |
| CDKN2A, BMP4, NFATC1, GSTP1 | Hyper | [117] |
| APC, RASSF1 | Hyper | [118] |
| IGF2 | Hypo | |
| SOCS1, APC, GSTP1 | Hyper | [119] |
| SMAD6, IFITM1, LRRC4, CHST4, TBX15 | Hyper | [120] |
| CCL20, NQO1 | Hypo | |
| p16, CDH1, p15, RUNX3, SFRP1, PRDM2, p14, RARβ, DAPK1, SOCS1, APC, RASSF1, MGMT, GSTP1 | Hyper | [121] |
| OCIAD2 | Hyper | [122] |
| RASSF1A | Hyper | [123] |
| CDCA1, CDCA3, CDCA4, CDCA5, CDCA6, CDCA8 | Hypo | [124] |
| CDCA2, CDCA7 | Hyper | |
| MTFR2 | Hyper | [125] |