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. 2022 Mar 24;41:107. doi: 10.1186/s13046-022-02297-2

Table 6.

Epigenetics drugs in trial for HCC

DRUGS Phase Reference
DNMTi
Guadecitabine (SGI-110) after sorafenib Phase II NCT01752933
Guadecitabine (SGI-110) + durvalumab Phase Ib NCT03257761
HDACi
Belinostat (PDX-101) Phase I/II NCT00321594
Tefinostat Phase I/II NCT02759601
Vorinostat + FOLFIRI Phase I NCT00537121
Panobinostat + sorafenib Phase I NCT00823290
Panobinostat + sorafenib Phase I NCT00873002
Resminostat + sorafenib Phase II NCT00943449
Resminostat + sorafenib Phase I/II NCT02400788
Vorinostat + sorafenib Phase I NCT01075113