Table 3.

GRADE assessment quality of evidence

[18F]FDG-PET/CT vs. no [18F]FDG-PET/CT in hospitalized adult patients with Staphylococcus aureus bacteremia Population: Hospitalized adult patients with Staphylococcus aureus bacteremia Intervention: 18F-FDG PET/CT Comparison: No 18F-FDG PET/CT
Outcome	N participants, n studies	Quality of the evidence (GRADE)
Mortality	880 participants, 5 studies	Low
New diagnostic findings detected by PET-CT	102 participants, 1 study	Very low
Infection relapse rate	778 participants, 4 studies	Very low
SAB-specific mortality	76 participants, 1 study	Very low
Change of antibiotic treatment duration and regimen	299 participants, 1 study	Very low
Performance of source control interventions	299 participants, 1 study	Very low

GRADE Working Group grades of evidence

High quality: The authors have a lot of confidence that the true effect is similar to the estimated effect

Moderate quality: The authors believe that the true effect is probably close to the estimated effect

Low quality: The true effect might be markedly different from the estimated effect

Very low quality: The true effect is probably markedly different from the estimated effect