Table 5.
Lipinski’s rule five for some compounds of medicinal plants against COVID-19 3CLpro protease protein.
| Sr. No | Compound name | Molecular weight(g/mol) | MLogP | Number of HBA | Number of HBD |
|---|---|---|---|---|---|
| Lipinski’s rule five | <500 | <5 | <10 | <5 | |
| 1 | (3,3-dimethylally) isoflavone | 78.41 | 1 | 6 | 1 |
| 2 | Licoleafol | 290.24 | 2.68 | 6.25 | 4 |
| 3 | Myricitrin | 136.10 | 1.19 | 5.24 | 2.6 |
| 4 | Thymoquinone | 286.21 | 1.97 | 8.24 | 3.13 |
| 5 | Salvinorin A | 372.21 | 2.33 | 3 | 3.02 |
| 6 | Bilobalide | 100.03 | −1.20 | 7 | |
| 7 | Citral | 354.12 | 0.88 | 5.42 | 2.31 |
| 8 | Ginkgolide A | 372.72 | 2.12 | 6 | 4 |
| 9 | Prephenazine | 258.33 | 2.25 | 7 | 1 |