eTable 2.
Logistic Regression Models of ICU Admission
| Variable | Model |
|||||||
|---|---|---|---|---|---|---|---|---|
| Asthma vs no asthma |
By asthma subtype |
|||||||
| GINA class |
Eosinophilic asthma |
ICS use |
||||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Asthma (yes vs no) | 1.58 (1.09-2.29) | .02 | — | — | — | — | — | — |
| GINA class | .01 | |||||||
| Moderate vs mild | — | — | 2.60 (1.03-6.54) | .04 | — | — | — | — |
| Severe vs mild | — | — | 0.73 (0.46-1.17) | .19 | — | — | — | — |
| Eosinophilic asthma | .05 | |||||||
| High vs low | — | — | — | — | 1.17 (0.57-2.40) | .67 | — | — |
| Unknown vs low | — | — | — | — | 0.66 (0.41-1.05) | .08 | — | — |
| ICS use | — | — | — | — | — | — | 1.37 (0.65-2.89) | .42 |
| Cohort: post vs pre 6/15 | 0.37 (0.28-0.48) | <.001 | 0.37 (0.28-0.47) | <.001 | 0.37 (0.28-0.48) | <.001 | 0.31 (0.14-0.67) | .003 |
| Age (per 1 y) | 1.01 (1.01-1.02) | .002 | 1.01 (1.00-1.02) | .003 | 1.01 (1.01-1.02) | .002 | 1.00 (0.98-1.03) | .86 |
| Female vs male | 0.57 (0.44-0.73) | <.001 | 0.57 (0.44-0.73) | <.001 | 0.57 (0.44-0.73) | <.001 | 0.46 (0.21-0.97) | .04 |
| Race | .85 | .84 | .85 | .70 | ||||
| Asian vs White | 1.10 (0.57-2.14) | .77 | 1.06 (0.54-2.06) | .87 | 1.09 (0.56-2.12) | .80 | — | .98 |
| Black vs White | 0.89 (0.65-1.20) | .44 | 0.88 (0.65-1.19) | .41 | 0.88 (0.65-1.20) | .43 | 1.55 (0.66-3.66) | .31 |
| Other vs White | 0.81 (0.51-1.30) | .39 | 0.80 (0.50-1.28) | .35 | 0.81 (0.51-1.29) | .37 | 2.03 (0.35-11.63) | .43 |
| Ethnicity | .26 | .27 | .23 | >.99 | ||||
| Hispanic vs non-Hispanic | 1.79 (0.88-3.66) | .11 | 1.76 (0.86-3.60) | .12 | 1.83 (0.90-3.74) | .10 | 0.91 (0.10-8.27) | .94 |
| Unknown vs non-Hispanic | 1.20 (0.65-2.23) | .55 | 1.22 (0.66-2.27) | .52 | 1.21 (0.66-2.24) | .54 | 1.00 (0.08-13.11) | >.99 |
| Transfer vs ED | 5.38 (3.90-7.43) | <.001 | 5.37 (3.89-7.42) | <.001 | 5.36 (3.88-7.39) | <.001 | 8.74 (2.77-27.61) | <.001 |
| OSA | 1.40 (1.00-1.95) | .04 | 1.45 (1.04-2.02) | .03 | 1.40 (1.00-1.95) | .04 | 1.54 (0.68-3.48) | .30 |
| COPD | 1.39 (0.88-2.19) | .16 | 1.41 (0.90-2.23) | .14 | 1.38 (0.88-2.18) | .16 | 1.38 (0.33-5.80) | .66 |
| Hypertension | 1.02 (0.77-1.35) | .89 | 1.04 (0.78-1.37) | .81 | 1.02 (0.77-1.35) | .90 | 0.64 (0.27-1.51) | .31 |
| CAD | 0.94 (0.65-1.38) | .76 | 0.94 (0.65-1.38) | .76 | 0.93 (0.64-1.36) | .72 | 2.19 (0.73-6.62) | .16 |
| Diabetes mellitus | 1.54 (1.16-2.05) | .003 | 1.53 (1.15-2.04) | .004 | 1.54 (1.16-2.05) | .003 | 1.18 (0.48-2.90) | .71 |
| Obesity | 1.08 (0.84-1.40) | .55 | 1.07 (0.83-1.38) | .61 | 1.08 (0.83-1.39) | .58 | 1.42 (0.63-3.17) | .39 |
| Charlson score (per 1 point) | 0.97 (0.93-1.01) | .16 | 0.97 (0.93-1.01) | .16 | 0.97 (0.93-1.01) | .18 | 0.99 (0.88-1.12) | .88 |
| Smoking status | .002 | .001 | .002 | .90 | ||||
| Current/former vs never | 1.33 (1.00-1.78) | .04 | 1.33 (1.00-1.78) | .05 | 1.33 (1.00-1.77) | .05 | 1.03 (0.44-2.44) | .94 |
| Unknown vs never | 1.80 (1.29-2.50) | <.001 | 1.82 (1.31-2.53) | <.001 | 1.79 (1.29-2.49) | .001 | 0.80 (0.28-2.32) | .68 |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ED, emergency department; GINA, Global Initiative for Asthma; ICS, inhaled corticosteroid; OR, odds ratio; OSA, obstructive sleep apnea.