eTable 3.
Logistic Regression Models of Mechanical Ventilation
| Variable | Model |
|||||||
|---|---|---|---|---|---|---|---|---|
| Asthma vs no asthma |
By asthma subtype |
|||||||
| GINA class |
Eosinophilic asthma |
ICS use |
||||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Asthma (yes vs no) | 1.58 (1.02-2.44) | .04 | — | — | — | — | — | — |
| GINA class | .003 | |||||||
| Moderate vs mild | — | — | 2.62 (0.97-7.05) | .06 | — | — | — | — |
| Severe vs mild | — | — | 0.65 (0.38-1.13) | .13 | — | — | — | — |
| Eosinophilic asthma | .09 | |||||||
| High vs low | — | — | — | — | 1.06 (0.46-2.42) | .89 | — | — |
| Unknown vs low | — | — | — | — | 0.61 (0.36-1.05) | .08 | — | — |
| ICS use | — | — | — | — | — | — | 1.35 (0.52-3.49) | .53 |
| Cohort: post vs pre 6/15 | 0.34 (0.25-0.48) | <.001 | 0.35 (0.25-0.48) | <.001 | 0.35 (0.25-0.48) | <.001 | 0.23 (0.08-0.64) | .01 |
| Age (per 1 y) | 1.00 (0.99-1.02) | .34 | 1.00 (0.99-1.02) | .37 | 1.01 (0.99-1.02) | .34 | 1.02 (0.98-1.05) | .42 |
| Female vs male | 0.47 (0.34-0.65) | <.001 | 0.46 (0.34-0.64) | <.001 | 0.47 (0.34-0.64) | <.001 | 0.35 (0.14-0.89) | .03 |
| Race | .94 | .95 | .94 | .81 | ||||
| Asian vs White | 1.01 (0.43-2.37) | .98 | 0.96 (0.41-2.26) | .93 | 1.00 (0.43-2.35) | > .99 | — | .98 |
| Black vs White | 0.85 (0.59-1.24) | .40 | 0.85 (0.59-1.23) | .40 | 0.85 (0.59-1.23) | .39 | 1.70 (0.58-5.00) | .33 |
| Other vs White | 1.02 (0.59-1.76) | .95 | 0.99 (0.57-1.72) | .98 | 1.01 (0.58-1.74) | .97 | 1.09 (0.13-8.94) | .94 |
| Ethnicity | .34 | .37 | .31 | .81 | ||||
| Hispanic vs non-Hispanic | 1.87 (0.80-4.36) | .15 | 1.84 (0.78-4.31) | .16 | 1.92 (0.82-4.48) | .13 | 0.71 (0.04-11.69) | .81 |
| Unknown vs non-Hispanic | 0.98 (0.48-1.99) | .95 | 0.99 (0.48-2.05) | .99 | 0.98 (0.48-2.01) | .96 | 0.40 (0.02-6.64) | .52 |
| Transfer vs ED | 7.86 (5.56-11.10) | <.001 | 7.94 (5.62-11.24) | <.001 | 7.85 (5.56-11.08) | <.001 | 42.85 (9.95-184.64) | <.001 |
| OSA | 1.35 (0.90-2.02) | .14 | 1.39 (0.93-2.07) | .11 | 1.34 (0.90-2.01) | .15 | 2.26 (0.80-6.35) | .12 |
| COPD | 0.80 (0.44-1.45) | .47 | 0.84 (0.46-1.52) | .56 | 0.80 (0.44-1.45) | .47 | 0.12 (0.01-1.09) | .06 |
| Hypertension | 0.99 (0.70-1.39) | .95 | 1.01 (0.72-1.42) | .96 | 0.99 (0.70-1.39) | .95 | 0.92 (0.30-2.79) | .89 |
| CAD | 0.78 (0.48-1.27) | .32 | 0.78 (0.48-1.26) | .31 | 0.78 (0.48-1.26) | .31 | 0.73 (0.18-2.99) | .66 |
| Diabetes mellitus | 1.71 (1.21-2.43) | .002 | 1.72 (1.21-2.43) | .002 | 1.72 (1.21-2.43) | .002 | 2.07 (0.70-6.09) | .19 |
| Obesity | 1.57 (1.15-2.15) | .005 | 1.56 (1.14-2.13) | .01 | 1.56 (1.14-2.14) | .01 | 1.23 (0.45-3.33) | .69 |
| Charlson score (per 1 point) | 0.97 (0.92-1.02) | .22 | 0.97 (0.92-1.02) | .20 | 0.97 (0.92-1.02) | .22 | 1.03 (0.88-1.20) | .72 |
| Smoking status | <.001 | <.001 | <.001 | .71 | ||||
| Current/former vs never | 1.49 (1.04-2.14) | .03 | 1.50 (1.05-2.15) | .03 | 1.49 (1.04-2.13) | .03 | 1.39 (0.49-3.96) | .54 |
| Unknown vs never | 2.84 (1.94-4.16) | <.001 | 2.89 (1.97-4.24) | <.001 | 2.84 (1.94-4.15) | <.001 | 0.79 (0.21-2.99) | .73 |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ED, emergency department; GINA, Global Initiative for Asthma; ICS, inhaled corticosteroid; OR, odds ratio; OSA, obstructive sleep apnea.