eTable 6.
Variable | Model |
|||||||
---|---|---|---|---|---|---|---|---|
Asthma vs no asthma |
By asthma subtype |
|||||||
GINA class |
Eosinophilic asthma |
ICS use |
||||||
RR (95% CI) | P | RR (95% CI) | P | RR (95% CI) | P | RR (95% CI) | P | |
Asthma (yes vs no) | 1.30 (1.09-1.55) | .003 | — | — | — | — | — | — |
GINA class | <.001 | |||||||
Moderate vs mild | — | — | 2.01 (1.29-3.14) | .002 | — | — | — | — |
Severe vs mild | — | — | 0.80 (0.65-1.00) | .04 | — | — | — | — |
Eosinophilic asthma | .001 | |||||||
High vs low | — | — | — | — | 0.85 (0.61-1.19) | .34 | — | — |
Unknown vs low | — | — | — | — | 0.69 (0.55-0.86) | .001 | — | — |
ICS use | — | — | — | — | — | — | 0.93 (0.68-1.29) | .68 |
Cohort: post vs pre 6/15 | 0.57 (0.50-0.64) | <.001 | 0.58 (0.52-0.65) | <.001 | 0.57 (0.51-0.64) | <.001 | 0.52 (0.37-0.74) | <.001 |
Age (per 1 y) | 1.00 (1.00-1.01) | .07 | 1.00 (1.00-1.01) | .09 | 1.00 (1.00-1.01) | .05 | 1.00 (0.99-1.01) | .83 |
Female vs male | 0.77 (0.69-0.86) | <.001 | 0.76 (0.68-0.85) | <.001 | 0.77 (0.68-0.86) | <.001 | 1.15 (0.82-1.62) | .41 |
Race | .17 | .17 | .17 | .55 | ||||
Asian vs White | 0.97 (0.72-1.30) | .85 | 0.96 (0.71-1.28) | .76 | 0.97 (0.73-1.30) | .85 | 0.49 (0.17-1.44) | .20 |
Black vs White | 0.91 (0.79-1.05) | .19 | 0.92 (0.80-1.05) | .22 | 0.91 (0.79-1.04) | .18 | 1.04 (0.69-1.57) | .85 |
Other vs White | 0.84 (0.67-1.04) | .10 | 0.83 (0.67-1.03) | .09 | 0.83 (0.67-1.03) | .10 | 0.76 (0.33-1.77) | .52 |
Ethnicity | .22 | .23 | .23 | .53 | ||||
Hispanic vs non-Hispanic | 1.32 (0.96-1.81) | .09 | 1.30 (0.95-1.78) | .10 | 1.31 (0.95-1.79) | .10 | 1.10 (0.44-2.75) | .83 |
Unknown vs non-Hispanic | 1.05 (0.80-1.38) | .72 | 1.07 (0.81-1.40) | .64 | 1.05 (0.80-1.38) | .73 | 0.57 (0.19-1.72) | .32 |
Transfer vs ED | 2.58 (2.22-3.00) | <.001 | 2.56 (2.21-2.98) | <.001 | 2.57 (2.21-2.99) | <.001 | 4.05 (2.48-6.62) | <.001 |
OSA | 1.02 (0.88-1.19) | .78 | 1.05 (0.91-1.22) | .50 | 1.03 (0.88-1.19) | .74 | 1.05 (0.74-1.49) | .79 |
COPD | 0.96 (0.77-1.21) | .75 | 0.99 (0.79-1.23) | .91 | 0.97 (0.77-1.21) | .76 | 0.74 (0.36-1.50) | .40 |
Hypertension | 0.98 (0.86-1.11) | .77 | 1.00 (0.88-1.14) | >.99 | 0.99 (0.87-1.12) | .85 | 0.70 (0.47-1.03) | .07 |
CAD | 0.91 (0.76-1.08) | .27 | 0.92 (0.77-1.09) | .33 | 0.90 (0.76-1.08) | .26 | 0.92 (0.53-1.58) | .75 |
Diabetes mellitus | 1.36 (1.19-1.56) | <.001 | 1.37 (1.20-1.56) | <.001 | 1.36 (1.19-1.55) | <.001 | 1.44 (0.95-2.18) | .09 |
Obesity | 0.96 (0.85-1.08) | .49 | 0.93 (0.83-1.05) | .25 | 0.95 (0.85-1.07) | .43 | 1.20 (0.83-1.73) | .34 |
Charlson score (per 1 point) | 1.02 (1.00-1.04) | .09 | 1.01 (0.99-1.03) | .26 | 1.02 (1.00-1.04) | .11 | 1.08 (1.02-1.15) | .01 |
Smoking status | .005 | .01 | .01 | .09 | ||||
Current/former vs never | 1.24 (1.09-1.41) | .001 | 1.23 (1.08-1.40) | .002 | 1.23 (1.08-1.39) | .002 | 1.39 (0.95-2.02) | .09 |
Unknown vs never | 1.02 (0.87-1.20) | .77 | 1.03 (0.88-1.21) | .71 | 1.02 (0.87-1.20) | .80 | 0.77 (0.46-1.26) | .29 |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ED, emergency department; GINA, Global Initiative for Asthma; ICU, intensive care unit; ICS, inhaled corticosteroid; OSA, obstructive sleep apnea; RR, risk ratio.