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Total anti-Spike Ig antibodies in previously SARS-CoV-2-uninfected and previously SARS-CoV-2-infected patients with CVID (green circles) or XLA (red squares) before vaccination (T0) and 4 weeks after the second dose (T2) of mRNA-1273 or BNT162b2 vaccine. The bars show the median values. Previously uninfected patients: 49 with CVID and five with XLA. Previously infected patients: 11 with CVID and one with XLA
