Table 3.

Association of total fat and total lean mass with total BMD in individuals with and without obesity

	Total cohort			Without obesity (BMI<30 kg/m2)			With obesity (BMI>30 kg/m2)
	N	sβ	p-value	N	sβ	p-value	N	sβ	p-value
Men (n = 2,097)
Lean mass	2097	0.57	1.51 × 10−126	732	0.56	3.52 × 10−84	365	0.45	3.00 × 10−11
Fat mass	2097	0.29	4.63 × 10−40	1732	0.19	8.41 × 10−15	365	0.02	0.78
Fat mass adj lean mass	2097	0.10	1.33 × 10−05	1732	0.13	8.50 × 10−09	365	0.01	0.91
Fat mass adj HOMA IR*	2097	0.14	3.01 × 10−10	1732	0.18	1.09 × 10−14	365	0.07	0.18
Lean mass adj fat mass	2097	0.51	2.45 × 10−25	1732	0.49	6.01 × 10−16	365	0.46	1.42 × 10−19
Women (n = 2,802)
Lean mass	2802	0.49	1.16 × 10−113	2376	0.44	5.49 × 10−63	426	0.37	7.01 × 10−09
Fat mass	2802	0.31	1.10 × 10−58	2376	0.20	9.53 × 10−22	426	−0.03	0.66
Fat mass adj lean mass	2802	0.13	4.92 × 10−11	2376	0.14	1.13 × 10−11	426	−0.13	0.015
Fat mass adj HOMA IR*	2802	0.17	1.84 × 10−15	2376	0.17	1.31 × 10−15	426	−0.11	0.043
Lean mass adj fat mass	2802	0.40	1.25 × 10−98	2376	0.38	8.02 × 10–84	426	0.43	2.09 × 10−16

Sβ represents corresponding SD increase in total BMD with one SD increase in fat and lean mass. Data presented for z-transformed fat and lean mass. All linear regression models adjusted additionally for age, height, smoking status, alcohol intake, physical activity and menopausal status in women.

*fat mass, lean mass and HOMA IR adjusted.