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. 2022 Mar 23;42(12):2570–2583. doi: 10.1523/JNEUROSCI.2029-21.2022

Figure 5.

Figure 5.

Interactions of loneliness with SA. A, Moderation analyses revealed that the positive association of SA with right amygdala activation during risky social decision-making (risky decision human – safe decision human) as observed in participants with LL (β = 0.63, p = 0.007, 95% CI: [0.18, 1.08]) was not evident in participants with HL (β = −0.26, p = 0.17, 95% CI: [−0.63, 0.11]). B, Likewise, the positive relationship of SA with right amygdala activation during social decision-making contrasted with risky decisions involving a computer partner vanished in the HL group (LL: β = 0.69, p = 0.003, 95% CI: [0.25, 1.14]; HL: β = 0.07, p = 0.72, 95% CI: [−0.30, 0.43]). C, Moreover, the nonsignificant negative association of SA with the subjective value of engaging in a social situation (i.e., CE50, the payoff offered in the safe option associated with 50% of safe decisions) in the LL group (β = −0.17, p = 0.48, 95% CI: [−0.64, 0.30]) was reversed in the HL group (β = 0.40, p = 0.049, 95% CI: [0.002, 0.80]). Thus, higher SA symptomatology was even associated with increased subjective values of engaging in social situations for participants suffering from loneliness. Dashed lines indicate the 95% CI of the plotted regression lines.