Figure 11.

Summary of findings observed in Pten KO animals. Nerve injury in PTEN-deficient MNs results in P-Akt upregulation (green arrow), which was accompanied by elevated P-CREB levels. P-CREB reflects activated CREB, which might enhance axonal regeneration through RAG expression. In addition, P-Akt may phosphorylate and thereby inhibit PRAS40, which in turn prevents PRAS40 from inhibiting mTOR. Thus, overall activation of growth-promoting mTOR achieved by PTEN deletion might also contribute to enhanced peripheral nerve regeneration. For this, P-mTOR might activate its effector 4EBP1, whereas no effects were seen on the S6 pathway. Created with BioRender.com.