Fig. 2.

Characterization of BrCa-specific SMFs. (A) The age and stage distribution of 169 BrCa patients and age distribution of 21 BBD patients as well as 135 HDs. (B) Three typical mass spectra at the m/z range of 100 to 400 are shown for serum samples of BrCa, BBD, and HD on the Left, while the frequency distribution of similarity scores on the Right was calculated for each group by SMFs within the same group. (C) A heat map of independent metabolic fingerprints for 325 serum samples was plotted using 301 m/z signals through data preprocessing. The color scale was processed by logarithmic correction. (D) The OPLS-DA classification for the BrCa (red points), BBD (yellow points), and HD (green points) group.