Table 3.
Odds for adverse cardiac outcome (cardiac transplantation or LVAD, or death from heart disease) in 101 lamin A/C genotype patients in univariate and multivariate mixed model logistic regression
| Univariate |
Multivariate Adjusted for age, sex, LVEF, NYHA functional class, and comorbidities |
|||||
|---|---|---|---|---|---|---|
| OR | CI | P | OR | CI | P | |
| Age per year | 1.3 | 1.21–1.42 | <0.001 | NA | NA | NA |
| Female | 0.4 | 0.06–2.80 | 0.36 | NA | NA | NA |
| Proband | 160 | 2.2–11 925 | 0.02 | 3.5 | 0.6–21 | 0.17 |
| NYHA I–IV | 30 | 11–84 | <0.001 | NA | NA | NA |
| LVEF per 5% | 2.5 | 1.9–3.3 | <0.001 | NA | NA | NA |
| LVGLS per % | 1.5 | 1.3–1.7 | <0.001 | NA | NA | NA |
| LVEDV per 10 mL | 1.5 | 1.2–1.9 | 0.001 | 1.2 | 1.006–1.4 | 0.04 |
| LAVI per 5 cm3/m2 | 1.6 | 1.3–2.0 | <0.001 | 1.0 | 0.8–1.1 | 0.65 |
| MR per 0–3 | 20 | 6.1–69 | <0.001 | 2.4 | 1.004–6.0 | 0.049 |
| RVLS per % | 1.7 | 4.7–42 | <0.001 | 1.3 | 1.03–1.65 | 0.03 |
| RVD per 3 mm | 3.0 | 1.4–2.1 | <0.001 | 1.5 | 1.1–2.1 | 0.01 |
| RA area per 5 cm2 | 4.6 | 2.5–8.8 | <0.001 | 1.3 | 0.8–2.0 | 0.28 |
| TR per 0–3 | 158 | 11.3–2182 | <0.001 | 5.0 | 1.64–14.8 | <0.01 |
| TAPSE per 3 mm | 3.1 | 2.1–4.6 | <0.001 | 1.4 | 0.96–2.0 | 0.08 |
P values by mixed models logistic regression analyses. Comorbidities included hypertension, coronary artery disease, peripheral arterial disease, cerebrovascular disease, and diabetes mellitus.
Parameters LAVI, LVEDV LVEF, RA area, RVD, and TAPSE are all continuous scale parameters.
LAVI; left atrial volume index, LVEDV; left ventricular end-diastolic volume, LVEF; left ventricular ejection fraction, LVGLS; left ventricular global longitudinal strain, MR; mitral regurgitation, NYHA; New York Heart Association functional class, OR; odds ratio, RA; right atrium, RVD; right ventricular basal linear dimension, RVLS; right ventricular longitudinal strain, TAPSE; tricuspid annular plane systolic excursion, TR; tricuspid regurgitation.