Table 8.
Major studies evaluating the diagnostic performance of CCTA at patient level for the detection of obstructive CAD (coronary stenosis ≥ 50%) in TAVI candidates
| Trial | Pontone et al.131 | Andreini et al.126 | Hamdan et al.127 | Harris et al. 128 | Opolski et al.130 | Matsumoto et al.129 | Rossi et al.132 | Strong et al.133 |
|---|---|---|---|---|---|---|---|---|
| Sample size | 60 | 325 | 115 | 100 | 475 | 60 | 140 | 200 |
| Prevalence of obstructive CAD (%) | 43 | N/A | 43 | 73 | 57 | 40 | 41 | 34 |
| Sensitivity (95% CI) | 88 (76–100) | 89a | 96a | 98 (92–100) | 98 (95–99) | 91a | 91 (81–96) | 100 (94–100) |
| Specificity (95% CI) | 88 (77–99) | 90a | 73a | 55 (35–74) | 37 (30–44) | 58a | 54 (44–65) | 42 (33–50) |
| PPV (95% CI) | 85 (72–99) | 80a | 72a | 85 (76–92) | 67 (62–72) | 59a | 58 (48–68) | 47 (44–51) |
| NPV (95% CI) | 91 (81–100) | 95a | 96a | 93 (69–99) | 94 (86–98) | 91a | 90 (78–95) | 100 (92–100) |
| Coronary stents included | + | + | + | + | + | - | - | - |
| CABG included | + | + | + | + | + | - | - | - |
a
95% confidence intervals not reported in the original study.
CABG, coronary artery by-pass graft; CAD, coronary artery disease; CI, confidence intervals; N/A, not available; NPV, negative predictive value; PPV, positive predictive value.