Table 1.
Description of included studies.
| Study | Country | Date | Setting | Number of Participants | Diagnosis | Main Outcome (Scale Details) | Duration of the Study | Intervention | Comparator |
|---|---|---|---|---|---|---|---|---|---|
| Gwak et al., 2020 [28] | Korea | March 2016–September 2017 | Multicentre 10 sites |
71 | DFU ≥ 1 cm2 post debridement and no clinical signs of infection | Proportion of patients with complete wound healing | 8 weeks | PVP-I 44.4% (16/36) |
Saline 44.1% (15/35) |
| Raju et al., 2019 [32] | India | March 2016–March 2017 | Multicentre 15 sites |
124 | Chronic ulcers (single VLU, DFU, PU with adequate arterial blood supply) | Proportion of patients with complete wound healing | 12 weeks | Cadexomer iodine ointment: 65.9% (27/41) Cadexomer iodine powder: 58.1% (25/43) |
Saline 20% (8/40) |
| Bellingeri et al., 2016 [30] | Italy | June 2010–December 2013 | Multicentre 6 sites |
289 | PU less than 80 cm2 | Wound improvement measured by BWAT scale tool | 4 weeks | PHMB | Saline |
| Vanscheidt et al., 2011 [29] | Germany, France, Hungary, UK | November 2007–December 2009 | Multicentre 15 sites |
126 | Chronic venous ulcer locally infected | Time to complete wound healing Proportion of patients with complete wound healing |
12 weeks | Octenidine 92 days 30.6% (15/49) |
Saline 87 days 32.0% (16/50) |
| Sibbald et al., 2011 [33] | Canada | February 2008–April 2009 | Multicentre 2 sites |
40 | Chronic wounds > 1 cm2 | Healing rate | 4 weeks | PHMB 35% reduction in wound surface |
Saline 28% reduction in wound surface |
| Holloway et al., 1989 [31] | USA | NG | Multicentre 3 sites |
75 | At least a venous stasis ulcer present for a minimum of 3 months | Healing rate | 24 weeks | Cadexomer iodine 0.95 cm2 per week |
Saline 0.41 cm2 per week |
BWAT, Bates Jensen Wound Assessment Tool; DFU, diabetic foot ulcer; NG, not given; PHMB, polyhexamethylenebiguanide; PU, pressure ulcer; PVP-I, povidone-iodine; VLU, venous leg ulcer.