Figure 19.

Partial structure predicted for Amyc. suaedae tetraene. The BGC contains genes for a AmphN P450 homologue (63% identity) that forms the exocyclic carboxyl group and genes for two further cytochrome P450 enzymes (WP_130475496.1 and WP_130475500.1) homologous to SelL (47% identity) and Lcm10 (47% identity). The modifications catalyzed by these enzymes cannot be predicted. Lcm10 catalyzes epoxide formation in lucensomycin. There are also genes for biosynthesis of additional deoxyhexoses and two further GT genes (see Section 10).