Figure 1.

Comparative profile of the amino acid sequences of HLA-E, HLA-G, and HLA-F, and a partial profile of the sequences of mice equivalent of HLA-E, known as Qa1^b. The amino acid sequences of HLA-E are compared with the amino acid sequences of HLA-G and HLA-F, and also with 504 HLA-A, 844 HLA-B, and 283 HLA-C alleles, to determine the HLA-E specific sequences. The HLA-E specific sequences in α1 and α2 helical domains are shown within the red boxes. HLA-Ib shared epitopes area are shown in black and blue boxes. Sequences in the blue boxes are shared with all HLA-Ia isoforms, while those in black boxes are shared with most, if not all, HLA-Ia alleles.