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. 2022 Mar 2;11(1):18. doi: 10.3390/antib11010018

Table 9.

Evolving HLA-ER and HLA-EG mAbs: HLA-Ib mAbs also react to all HLA-Ia isoform alleles.

Groups R-VII R-VIII R-IX R-X G-VIII G-IX G-X
MFI Expressed in Thousands
Subgroups [A] [B] [C] [A] [B]
Number of mAbs 1 1 2 1 1 2 1 2 3 4 5 6 7 8 9 10 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 1 2 3 4
mAb Nomenclature TFL-063 TFL-103 TFL-104 TFL-049 TFL-006 TFL-007 TFL-227 TFL-197 TFL-198 TFL-202 TFL-203 TFL-204 TFL-210 TFL-211 TFL-212 TFL-235 TFL-230 TFL-256 TFL-224 TFL-214 TFL-213 TFL-215 TFL-225 TFL-233 TFL-240 TFL-238 TFL-236 TFL-237 TFL-239 TFL-234 TFL-248 TFL-229 TFL-232 TFL-177 TFL-176 TFL-198
IgG Subclass IgG2b IgG1 IgG1 IgG2b IgG2a IgG2a IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG3 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG1 IgG2b IgG3 IgG1 IgG1 IgG1
HLA-ER Reactivity 22+ 18 17+ 15 22+ 21+ 18 17 16 18 18 17+ 19 18 18 21 0 22+ 22 20+ 21 21 19 19+ 18 18 19 20 19+ 19 21+ 30 22+ 14+ 13+ 15
HLA-EG Reactivity 18+ 16 15 17+ 16+ 16+ 17+ 17+ 18 19+ 18+ 22 20+ 21+ 20 20+ 19+ 18 19+ 19+ 18 21 27+ 21
HLA-F Reactivity 3+ 8+ 12+ 11 5+ 10+ 10 11 10+ 10+ 11 11 11 9 2+ 5 4+ 10
HLA-G Reactivity 4+ 4+ 7+ 7+ 2+ 1 1 1 2 2+ 2+ 1 1+ 11+ 14 13+ 9+ 8 10 2 18+ 21+ 11 11 0+
HLA-A Reactivity A*0101 2 1 5+ 13 1 1 1 4 0 0 0
A*0201 3
A*0203 1 2+ 2 2+ 2+ 2+ 2 2 2 4+ 2
A*0206 1 3+ 2+ 3+ 3+ 3+ 3 3 3 4+ 0 0 2+
A*0301 3 7 5+ 8+ 5 5 3+ 3 3+ 10 5+
A*1101 2 6 6 1 10 8 4 11 10 11+ 11+ 11 11+ 11 11 11 4+ 4+ 4+ 5 5 5+ 5+ 5+ 5+ 5 5+ 7 6+ 7 7+ 9+ 3+ 4 10
A*1102 3 1 1 1+ 1 1 1 1 1 9 1
A*2301 3+ 9+ 8 11 10 10+ 10 10 10 11 8
A*2402 2+ 3 3 2 4+ 14+ 13 15+ 14+ 14+ 14 14 14+ 12+ 1 1+ 1 1 1+ 1+ 1 1 2+ 2+ 3 1+ 2+ 1+ 1+ 13
A*2403 2+ 2+ 3 1+ 4+ 12+ 11 13+ 13+ 13 13+ 12+ 13 12 1 1 1+ 1 1 1 11
A*2501 1 4
A*2601 3 1+ 1 1 1+ 1 1 1 1 1 8 2 2+ 2+ 2+ 2 2+ 1+ 2 2 2 1
A*2901 1+ 1+ 3 2 5 4+ 6+ 5 5 4+ 4 4+ 6+ 1 1 1 1 1 1 1+ 4+
A*2902 2 1 6+ 5 7+ 6 5+ 4+ 4 4+ 6 0 0 5
A*3001 2 1 5 5 4 6+ 4+ 4+ 4 3+ 4 12 1+ 1 1+ 1 1 4
A*3002 1 1 3 2 3 7 6 8 6+ 6+ 6+ 6 6+ 9+ 1 1 1 1 6
A*3101 4 3 5 3 3+ 2+ 2 2 3 3
A*3201 1 1 2 1+ 3+ 2+ 4+ 3 3 2+ 2+ 2+ 5 1 1 1 1 1 2+
A*3301 1 1 2+ 1+ 6+ 5+ 7+ 6+ 6+ 5+ 5 5+ 5+ 1 1 1 1 1 1 5+
A*3303 2 2 4 2+ 1+ 7 6+ 8 7 7+ 7+ 7+ 7+ 8+ 1 1 1 1+ 1 1 1 1+ 6+
A*3401 1+ 1+ 6 3+ 1+ 1 1+ 1+ 1+ 1+ 1+ 1+ 3+ 1
A*3402 1 4 4+ 4 5 4+ 5 5 4+ 5 11+ 1 0 1 4
A*3601 2 2 5+ 3+ 1 1 1 1 1 1 1 1 8+ 1 1 1 1 1 1 1 1
A*4301 1 4 2 5
A*6601 3+ 1+ 6+ 5+ 7+ 6+ 6+ 5+ 5 5 4+ 5+
A*6602 1 3+ 3 4+ 3+ 3+ 3 3 3 2+ 3
A*6801 1 5+ 4+ 6+ 5+ 5+ 5 4 4+ 5 4+
A*6802 1 1 2 1 2 1+ 2 2 2 1+ 1+ 1+ 8 1+ 2 1+
A*6901 1+ 6+ 5 7+ 5+ 5 3+ 3+ 4 4+ 5
A*7401 1 2+ 2 2+ 2+ 2+ 2+ 2 2+ 10 1 1 1+ 1 1 1 2
A*8001 2+ 1 2 13 13 13+ 13 13 13 12+ 12+ 9 13
HLA-B Reactivity B*0702 1 4+ 18 17+ 18+ 18 18 17+ 17 18 13+ 2 1+ 2 17+
B*0801 2 1 7 2+ 2 3 2+ 2+ 2+ 2+ 2+ 15 1 1 1 1 1 1+ 1+ 1+ 2 2 2 19+ 19+ 19+ 2+ 24+ 1+ 2 2 2
B*1301 2 2+ 5+ 3+ 8+ 18+ 19 19_ 19 18+ 18+ 18 18+ 16 2 2 2 2+ 2+ 2+ 2+ 2+ 3+ 3 3 19 20+ 19+ 4+ 24 3+ 3+ 4 18
B*1302 1 2 1 6 13+ 12+ 14+ 13+ 14 13+ 13+ 13+ 13+ 2 2 2 2+ 2+ 2+ 2+ 3 3 3 3+ 6 6 6 3+ 6+ 2+ 2+ 12+
B*1401 2 7 7 2 11 8+ 6 15+ 14+ 16 16 15+ 16 16 15+ 14 3 2+ 3 1+ 1 14+
B*1402 1+ 1+ 4 2+ 2 9+ 8 10 10 10+ 9+ 9 9+ 8+ 12+ 12+ 12+ 11+ 8
B*1501 1 4 5+ 4+ 6 5+ 6 5+ 5+ 5+ 11+ 1 1 1 1 1 1 1 1 1 1 16 16 16 2 18+ 1+ 2 4+
B*1502 3 3 6 4 6+ 19 18+ 19+ 19+ 19 19 18 18+ 15 1 1+ 1+ 2+ 2 2+ 5 8 1 1 18+
B*1503 1 1 2+ 1+ 6+ 16+ 16+ 17+ 17+ 17 17 16+ 18+ 14 1+ 1+ 1+ 1 1 1 16+
B*1510 2+ 1 1 8 7 8+ 8 8 7+ 7+ 7+ 6+ 8 7+ 8 5 7
B*1511 3 3+ 9 5+ 9 15 14+ 16 15+ 15+ 15+ 15 15+ 16+ 7+ 7+ 8 8+ 8+ 9 9 9 9 9 9+ 10+ 10 10+ 10+ 16 1 6 7 14+
B*1512 1+ 7 3+ 3 4+ 4 4 3+ 3 3+ 15 1 1 1 1 1 1 1 1 1+ 1+ 1+ 9 19 19+ 2 24 2+ 2 2+ 3
B*1513 2 2 5 3 6+ 1+ 1 1+ 1+ 1+ 1+ 1+ 1+ 15 19 19+ 18+ 22+ 4 1 1 1
B*1516 2 2 5+ 3 4+ 15 13+ 15+ 15+ 15 15 14+ 14+ 12 1 1 1 1 1 1 1 1 1 1 2 3 3 3 2+ 3 1+ 2 13+
B*1801 3+ 3+ 6+ 4+ 2 10+ 10 11+ 11 10+ 10+ 10+ 10+ 7+ 10
B*2705 2+ 1+ 1 8+ 7+ 8+ 8+ 8+ 8 7+ 8 6+ 7+
B*2708 1 1 4 2+ 4+ 5+ 4+ 6 5+ 5+ 5+ 5 5+ 11+ 1 1 1 1 1 1 1 1 1 2+ 2 2+ 2 2+ 2 2 4+
B*3501 2 6+ 6+ 1 10 8+ 7+ 19 19 20 19+ 18+ 18 18 18 16 1 1 1+ 1 1 1 3 3+ 3+ 8+ 8 9 2+ 8 9 2 2 19
B*3701 2+ 3 6 4 6 15+ 15 16 16 16+ 15+ 15+ 15+ 14 1 1 1 1 1 15
B*3801 3+ 1+ 3+ 13+ 12+ 14 13+ 13+ 13 12+ 13+ 11 2 2 3 3 3 4 4 4 4 5 12+
B*3901 3+ 3+ 7 5 7+ 19+ 19 20+ 20 19+ 19+ 18+ 19 15+ 1+ 2 1+ 2 2+ 2 2+ 3 19
B*4001 2+ 2+ 5+ 3+ 4+ 15+ 15 16+ 16 15+ 16 15 15+ 12+ 1 1 1 1 1 2 1+ 2 2 2 1 1 15
B*4002 3+ 3+ 6 4+ 6 4 3+ 4+ 4 4+ 4 4 4 14 1+ 1+ 1+ 1+ 1+ 2 2 1+ 2 2 2+ 3 3 3+ 3+ 4 2 2+ 3+
B*4006 7 11 11 3 15+ 13+ 4+ 3+ 5+ 4+ 4+ 4 3+ 4 3+ 1 1 1 1 1 1 3+
B*4101 3+ 3+ 7 5 3 15+ 15 15+ 15+ 15+ 15 15 15 10+ 15
B*4201 3 9+ 8+ 11 10 10 9+ 9 9 14+ 1 1 1 1 1+ 1+ 1 1 2+ 2+ 3 3+ 3+ 3+ 2+ 9+ 12+ 2+ 3 8+
B*4402 1+ 1+ 7 4 1+ 6+ 6 7+ 7 7 6 6 6 10 1+ 1+ 1+ 2 2 2 2 2 2 2 2 3+ 3+ 3+ 3+ 4+ 2 2+ 6
B*4403 4 4 7 5+ 3+ 1 1 11 1
B*4501 1 5 5+ 9+ 7+ 6+ 19 19 20+ 19+ 19 19 19 19 16 1 19+ 21 20 1+ 25 2 2 2 19
B*4601 2+ 2+ 6 4 6+ 17+ 17 19 17+ 18 17+ 17 18 14+ 1 1 1+ 1 2 1 1 1 17
B*4701 2 2 6+ 3+ 8+ 20 20 21 19+ 19+ 19 19 19 16 1+ 2 2+ 3+ 3 3+ 2 2 1+ 1+ 20
B*4801 1 1 4 2+ 7 14+
B*4901 5+ 13+
B*5001 8 4 3+ 4+ 4+ 4+ 4+ 4 4+ 15+ 1 1 1 1 1 1+ 1 1 1+ 1+ 1+ 5 4+ 5 2+ 3+ 2+ 2+ 3+
B*5101 1+ 1+ 6 3+ 7+ 1+ 1+ 2 1+ 1+ 1_ 1+ 1+ 15 2+ 2 2+ 1 1 1+ 1+ 1+
B*5102 2 2 5 3+ 7 2 1+ 2 2 2 2 2 2 15+ 3 2+ 3+ 1 1 1 1+
B*5201 1+ 1+ 4+ 2+ 9+ 10 9 11 10+ 10 10 9+ 10 15+ 5+ 5+ 5+ 6 6 6+ 6+ 6+ 6 6+ 6+ 8+ 9 9 8 12 5+ 6+ 9
B*5301 1 5+ 5+ 8+ 7 6+ 2+ 2+ 3 2+ 2+ 2+ 2+ 2+ 14 1 1 1 1 1 1 1 1 1+ 1+ 1+ 1+ 1+ 1+ 2 2+ 1+ 2 2+
B*5401 3 3+ 5+ 4 5 2+ 2+ 3 3 3 2+ 2+ 2+ 12+ 1 1 1 1 1 1 1 1 1+ 1+ 1+ 3+ 3 3+ 1 3 1+ 1+ 2+
B*5501 2+ 1+ 2 2+ 2 2+ 2+ 2+ 2 2 2 8 1 1 1 1 1 2
B*5601 1 2+ 4+ 3+ 4+ 4+ 4+ 4 4 4+ 10 1 1 1 1 1 1 1 12+ 12+ 12+ 2 13+ 1 1 3+
B*5701 5 5+ 4+ 6 5+ 5+ 5+ 5+ 5+ 13 1 1 1 1 1 1+ 1 1 1+ 1+ 1+ 17+ 18 17+ 2+ 21+ 2 2 4+
B*5703 1 7 12+ 11+ 13 12+ 12+ 12+ 12+ 12+ 13+ 5 5+ 5+ 6 6 6+ 6+ 6 6+ 6 6+ 8 8+ 8 8 12+ 1 5 5+ 11+
B*5801 2 6 6+ 1 10 8 9 2+ 2 2+ 2+ 2+ 2+ 2+ 2 17 1 1 1 1+ 1+ 1+ 1+ 1+ 2+ 2+ 2+ 6 5+ 6 2+ 5 1 2+ 3 2
B*5901 1 1 5+ 3 2 9 8 10 9+ 9+ 9 9 9 8+ 8
B*6701 4+ 4+ 4 5 4+ 4+ 4+ 4+ 4+ 11 2 2 2 2 2 1 1+ 4
B*7301 1 1 3 2 6+ 4 3+ 4 4 4 4 3+ 4 14 1 1 1 3 3 3 1+ 2 1+ 1+ 3+
B*7801 3 3+ 6 4+ 5 18+ 17+ 19 18+ 18+ 17+ 17+ 18 13+ 1 1 1 17+
B*8101 1 7+ 19+ 19+ 20+ 19+ 19+ 18+ 19+ 18+ 16 1 1 1 1+ 1+ 1 1 2 2+ 2+ 4+ 4+ 5 2+ 5+ 4 2 2 19+
B*8201 3 2+ 4 3 13 20 19 20+ 20 19+ 19+ 19+ 19+ 18+ 1+ 1+ 1+ 1 1 1 1+ 2+ 3 3 3+ 19
HLA-C Reactivity Cw*0102 7 3 11+ 20 29 20+ 20+ 20 20 19 19+ 18+ 1 1 1 2 2 2 2+ 19
Cw*0202 2+ 2+ 10+ 6 11 15+ 14 16+ 15+ 15+ 11 10+ 11 16 1 1 1 1 1 1 1 1+ 2 2 14
Cw*0302 1+ 1+ 5+ 3 10 15+ 1+ 2
Cw*0303 2 2+ 7 4 9+ 7+ 6+ 8+ 8 7+ 7 6+ 7 15+ 1 1 1 1 1 1+ 1+ 1+ 1+ 1+ 1+ 2 2+ 2+ 3 6+
Cw*0304 2 2 6+ 3+ 11 2 1+ 2+ 2+ 2+ 5+ 5 5 17 1 1+ 1+ 1+ 2+ 3+ 1+ 2 1+
Cw*0401 2+ 1 9+ 18 18 19+ 19+ 19 18 18+ 18 15+ 5 5 5+ 5+ 6 6 6+ 6 6 6 6 6+ 6+ 6+ 7+ 12+ 2 5+ 6 18
Cw*0501 4 8 8+ 2 16 13 13 7 6+ 8 7+ 7+ 12 12 12+ 18+ 2+ 3+ 3+ 1 1 1 1 5+ 13+ 2+ 2+ 6+
Cw*0602 1 1 9 4 16+ 5 4+ 6 5+ 5 10 9+ 10 18+ 1+ 2 2 1 4+ 9+ 6 7 4+
Cw*0702 12 6+ 10 19+ 17+ 19+ 19 19+ 18+ 18+ 19 17 4 5 5 5+ 5+ 5+ 6 6 6+ 6+ 10+ 1 5+ 6 17+
CW*0801 3 6 6+ 1+ 13 10+ 11 21+ 20 22 21 21 21 21 21 19 1 1+ 1+ 2+ 5 1 1+ 20+
Cw*1203 5 2 12 19+ 19+ 21 20 19+ 19+ 19 19 17 1 1 1+ 2 2 1+ 1 1+ 2 3 2+ 2+ 3 19+
Cw*1402 2 2 8+ 4+ 9 10+ 9+ 11 10+ 10 9+ 9+ 9+ 16+ 1+ 1+ 2+ 3 3 2 2 2+ 3 5 2+ 2 2+ 9+
Cw*1502 1+ 1+ 6 3 11 20+ 20+ 22 20+ 20 20 19+ 19+ 18+ 1 1 1 1+ 1+ 1+ 1+ 2 2 1 1+ 4 7+ 2+ 3 20+
Cw*1601 1 1+ 8 4 15+ 19+ 19+ 21 19+ 19 18+ 19 18+ 18 1 1+ 1+ 1+ 1 1 1 2 2+ 3+ 6 7 19+
Cw*1701 1+ 1+ 13+ 9 11 13 13 14 13+ 14 14 14+ 14+ 17 6 6 6 7 7 7+ 7+ 7+ 7+ 7+ 7+ 8 8 8 9 15 4 6 6+ 13
Cw*1802 8 11 11+ 4 17+ 15 8+ 9+ 8+ 10 9+ 9+ 9 9 9 16+ 1+ 1+ 2 2 2 2+ 2 2 3+ 3+ 3+ 19+ 20+ 10+ 4 24+ 3 3+ 4 6+