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. 2022 Mar 22;10:tkab049. doi: 10.1093/burnst/tkab049

Figure 3.

Figure 3.

Angiogenic Aptamer-modified tetrahedral framework nucleic acid promotes angiogenesis in vitro and in vivo. (a) Schematic diagram of tFNA, tFNA-Apt02, and tFNA-AptVEGF promoting angiogenesis in vivo. (b) Sprouting assay after treatment with nanoparticles. And semiquantification analysis of the number of sprouts. (c) Photographs of a Matrigel plug assay after treatment with nanoparticles (ss-DNA, Apt02, AptVEGF, tFNA, tFNA-Apt02, and tFNA-AptVEGF). Scale bars are 500 μm. (d) H&E staining of the gel plug assay and plenty of capillaries can be seen. Scale bars are 100 μm. And quantification analysis of the number of blood vessels with red blood cells. (*p<0.05, **p<0.01). tFNA tetrahedral framework nucleic acid, tFNA-Apt02 tetrahedral framework nucleic acid-aptamer 02 nanostructures, tFNA-AptVEGF tetrahedral framework nucleic acid-aptamer, VEGF nanostructures, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor [125]. (Copyright 2021 American Chemical Society)