Table 4.

Comparison of different delivery systems for nanomaterials

Delivery systems	Bioactive factors	Advantages	Drawbacks	References
Degradable polymers (Nanoparticle, nanofibers, etc.) Cationic polymers Liposomes	VEGF, bFGF, PDGF, LL37 NO Small interfering RNA, LL37, VEGF plasmid, PDGF plasmid bFGF, VEGF plasmid, PDGF plasmid, Ang-1 plasmid, KGF	Versatile degradation kinetics. Controlled drug release properties. Inherent wound healing property by supplying lactate byproducts. Intrinsic bio-adhesiveness to the mucosal surface of wound. Increased residence time due to similar lipoid composition to the skin. Superior drug penetration into skin. Strong hydrophobic interaction with drugs. Easy surface modification of liposomal membrane.	Collateral tissue damage caused by acidic byproducts. Dose limit due to their inherent cytotoxicity. Usage of organic solvent or oil for particle formation. Drug leakage. Coalescence issue	[20,37,38,45] [62,98,99,131] [41,105]
DNA nanomaterials	Tetrahedral framework nucleic acids	Good mechanical properties. Structural stability against nuclease degradation. Having the ability to access cells.	Mostly confined to in vitro studies.	[115,116,124,125]

VEGF vascular endothelial growth factor receptor, bFGF basicfibroblast growth factor, PDGF platelet-derived growth factor, Ang1 angiopoietin-1, KGF keratinocyte growth factor