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Effect of Vit. K2 administration on depressive-like behavior: forced swimming test (FST). (A) Swimming time (sec.), (B) Immobility time (sec.), and (C) Climbing time (sec.). The rats were orally gavaged with Vit. K2 (30 mg/kg) once daily 5 days per week for 17 months. Data are expressed as mean ± SE. Statistical analysis was conducted using (ANOVA) followed by Tukey–Kramer’s post hoc test, (n = 6, p ≤ 0.05). * Significance versus adult control; # significance versus aged control.
