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Effect of Vit. K2 administration on frontal cortex and hippocampal relative gene expression of (A) IL-6 and (B) Nrf-2. The rats were orally gavaged with Vit. K2 (30 mg/kg) once daily 5 days per week for 17 months. Data are expressed as mean ± SE. Statistical analysis was conducted using (ANOVA) followed by Tukey–Kramer’s post hoc test (n = 6, p ≤ 0.05). * Significance versus adult control; # significance versus aged control.
