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% area of immuno-staining cortical and hippocampal CD68 (A,B), TNF-alpha (C,D), Nrf2 (E,F) and tyrosine hydroxylase (G,H). Data are expressed as mean ± SE. Statistical analysis was conducted using (ANOVA) followed by Tukey–Kramer’s post hoc test, (n = 6, p ≤ 0.05). *** Significance versus adult control at p ˂ 0.001; **** Significance versus adult control at p ˂ 0.0001; ## significance versus aged control at p ˂ 0.01, #### at p ˂ 0.0001.
