Table 5.

Comparison between the best SSM THP1 and the state-of-the-art ML model to predict tumor-homing activity of benchmarking datasets.

Dataset	Method	Ac (%)	Sn (%)	Sp (%)	MCC
Main	TumorHPD	86.56	80.63	89.71	0.7
	THPep	86.1	87.07	85.18	0.72
	THP1	94.47	89.25	99.66	0.894
Small	TumorHPD	81.88	73.13	90.92	0.65
	THPep	83.37	81.24	85.81	0.67
	THP1	92.64	85.71	99.5	0.861
Main90	TumorHPD	89.66	83.64	80.68	0.74
	THPep	90.8	91.8	87.97	0.77
	THP1	99.18	98.3	99.54	0.98