TABLE 1.

Effects of AmB-AG conjugates and Fungizone on L. major and L. infantum promastigotes and amastigotes in vitro^a

Drug	ED50 (μg/ml) for in vitro activity against:
	L. major		L. infantum
	Promastigotes	Amastigotes	Promastigotes	Amastigotes
Fungizone	0.02	NDb	0.01	ND
rAmB-AG	0.34	0.31	0.06	0.035
uAmB-AG	0.19	0.17	0.03	0.027

^aThe effect on promastigotes was evaluated by [³H]thymidine incorporation, and the effect on amastigotes was evaluated by microscopic counting of macrophages and intracellular amastigotes. 

^bND, not done.