TABLE 2.
Effects of AmB-AG conjugates and AmBisome administered i.v. or s.c. on the time of lesion appearance in BALB/c micea
| Treatment (n) | No. of mice with lesions at the following time (wks) after infection:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
| Control (8) | 0 | 5 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| AmBisome | |||||||||
| i.v., 6 mg/kg (8) | 0 | 3 | 5 | 6 | 8 | 8 | 8 | 8 | 8 |
| s.c., 6 mg/kg (8) | 0 | 3 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| s.c., 12 mg/kg (8) | 0 | 0 | 2 | 5 | 6 | 6 | 7 | 7 | 7 |
| uAmB-AG | |||||||||
| i.v., 6 mg/kg (6) | 0 | 0 | 1 | 1 | 2 | 3 | 5 | 5 | 5 |
| s.c., 6 mg/kg (8) | 0 | 0 | 1 | 2 | 2 | 5 | 5 | 5 | 5 |
| s.c., 12 mg/kg (8) | 0 | 0 | 0 | 1 | 1 | 2 | 2 | 2 | 2 |
| rAmB-AG, s.c., 12 mg/kg (8) | 0 | 0 | 0 | 0 | 1 | 2 | 4 | 4 | 5 |
a
Treatment was started 2 days after injection of parasites.