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. 2022 Mar 14;11(3):551. doi: 10.3390/antiox11030551

Table 4.

Comparison of lipid peroxidation compounds between groups using Mann–Whitney test.

Lipids Healthy
vs.
MCI-AD		 Healthy
vs.
MD-AD		 Healthy
vs.
AD-AD		 Healthy
vs.
Non-AD		 MCI-AD
vs.
MD-AD		 MCI-AD
vs.
AD-AD		 MCI-AD
vs.
Non-AD		 MD-AD
vs.
AD-AD		 MD-AD
vs.
Non-AD
PGs a PGE2 <0.01 * 0.38 0.06 0.23 0.05 * 0.78 0.23 0.23 0.90
PGF2α 0.66 0.30 0.97 <0.01 * 0.16 0.79 <0.01 * 0.50 0.09
15-E2t-IsoP <0.01 * <0.01 * 0.01 * <0.01 * 0.99 0.37 0.09 0.52 0.09
15-F2t-IsoP 0.07 0.24 0.10 0.59 0.01 * 0.89 0.95 0.18 0.26
IsoPs a 15(R)-15-F2t-IsoP 0.65 0.51 0.21 0.20 0.20 0.23 0.07 0.12 0.31
2,3-dinor-15-epi-15-F2t-IsoP 0.48 0.19 0.40 0.22 0.46 0.61 0.40 0.91 0.73
15-keto-15-E2t-IsoP <0.01 * <0.01 * 0.03 * 0.11 0.08 0.57 0.11 0.79 0.73
15-keto-15-F2t-IsoP <0.01 * 0.42 0.19 0.18 0.02 * 0.76 <0.01 * 0.35 0.05 *
5-F2t-IsoP <0.01 * 0.06 0.01 * 0.31 0.16 0.47 <0.01 * 0.10 0.01 *
Total IsoPs <0.01 * 0.01 * <0.01 * 0.49 0.33 0.02 * 0.01 * <0.01 * 0.09
IsoFs a Total IsoFs <0.01 * 0.051 ^ <0.01 * 0.63 0.21 0.01 * 0.02 * <0.01 * 0.18
NeuroPs b 4(RS)-4-F4t-NeuroP <0.01 * <0.01 * 0.02 * 0.02 * 0.95 0.38 0.98 0.35 0.92
10-epi-10-F4t-NeuroP 0.72 0.18 0.55 <0.01 * 0.10 0.73 <0.01 * 0.34 <0.01 *
14(RS)-14-F4t-NeuroP 0.059 ^ 0.26 <0.01 * 0.99 0.26 0.07 0.17 <0.01 * 0.49
Total NeuroPs <0.01 * <0.01 * 0.15 0.28 0.73 0.98 0.34 0.98 0.12
NeuroFs b Total NeuroFs 0.73 0.39 <0.01 * 0.04 * 0.58 <0.01 * 0.054 ^ 0.02 * 0.14
Dihomo-IsoPs c 1a,1b-dihomo-PGF2α <0.01 * <0.01 * <0.01 * 0.78 0.26 0.14 <0.01 * 0.06 <0.01 *
Ent-7(RS)-7-F2t-dihomo-IsoP 0.01 * <0.01 * 0.08 0.02 * 0.01 * 0.57 0.51 0.60 0.35
17-F2t-dihomo-IsoP 0.56 0.04 * 0.51 0.06 0.08 0.42 0.13 0.21 0.82
17-epi-17-F2t-dihomo-IsoP <0.01 * <0.01 * 0.26 0.48 0.65 0.82 0.36 0.68 0.27
Dihomo-IsoFs c 17(RS)-10-epi-SC-Δ15-11-dihomo-IsoF 0.64 0.059 ^ 0.59 0.02 * 0.09 0.51 0.04 * 0.27 0.53
7(RS)-ST-Δ8-11-dihomo-IsoF 0.89 0.83 0.38 0.21 0.92 0.22 0.28 0.19 0.24

Notes: a = Lipid peroxidation compounds derived from the oxidation of AA; b = Lipids derived from the oxidation of DHA; c = Lipids derived from the oxidation of AdA; * p value < 0.05; ^ p value near to 0.05.