Table 2.

Comparison between enzybiotics and nanozybiotics for antibacterial application.

	Enzybiotics	Nanozybiotics
Derivation	natural enzymes	nanozymes (nanomaterials)
Catalytic activity	peptidoglycan hydrolases, proteases, and nuclease	peroxidase, oxidase, catalase, deoxyribonuclease
Main antibacterial mechanism	destroy bacterial cell structure	catalyze the production of ROS
Application advantages	rapid and unique mode of action, high specificity of kill pathogens, low probability for bacterial resistance development and a proteinaceous nature	economical, stable, with catalytic function without additional modification, easy to integrate a variety of antibacterial strategies
Application disadvantages	environmentally sensitive and unstable, high cost, short half-life and immunogenicity of proteins	low enzyme activity, limited types of enzyme catalysis and complicated toxicological profile