Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of the mechanism by which caloric restriction and physical activity prolong the lifespan and improve health, using 5′ adenosine monophosphate-activated protein kinase (AMPK) and reactive oxygen species (ROS) as mediators, and ROS generated through oxidative phosphorylation (OXPHOS)—schematic mechanism.
