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. 2022 Mar 6;11(3):508. doi: 10.3390/antiox11030508

Figure 6.

Figure 6

Histopathology of H&E-stained sections of the metaphysis of the femur in different studied groups. (a–c) Control, LDPE, and HDPE groups showed normal histology of epiphyseal plate, bone trabeculae, and osteoblastic rimming of cortical bone. (d) DEXA injected rats showed evident osteoporotic changes (thinned out the epiphyseal plate (×40), discontinuous thinned bony ossicles separated by the widened bone marrow, and increased fat content (×100), loss of osteoblastic rimming with increased osteoclastic activity with erosion cavity (×400)). (e–g) treated groups by different compounds showing reversal of osteoporotic changes in different degrees. Yellow arrows = epiphyseal plate. Black arrows (ob), osteoblasts; red arrow, osteoclasts; OC, osteocytes; LDPE, low-dose of date pit extract (150 mg/kg); HDPE, high-dose of date pit extract (300 mg/kg); DEXA, dexamethasone (1 mg/kg); LPDE + DEXA, low-dose of date pit extract + dexamethasone; HPDE + DEXA, high-dose of date pit extract + dexamethasone and IPRI + DEXA, ipriflavone (50 mg/kg) + dexamethasone.