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. 2022 Mar 18;119(12):e2114739119. doi: 10.1073/pnas.2114739119

Fig. 1.

Fig. 1.

TLR stimulation leads to LD accumulation through HILPDA and ATGL. (A and B) BODIPY staining and LD quantification in wild-type BMDMs treated with vehicle (Ctrl), P3C, LPS, flagellin, poly:IC, or zymosan for 24 h. (C and D) BODIPY staining in wild-type BMDMs treated with vehicle (Ctrl), LPS, LPS and C75, or LPS and atglistatin (ATGLi). (E) mRNA levels of Hilpda in wild-type BMDMs treated with vehicle (Ctrl), LPS, P3C, flagellin, poly:IC, or zymosan for 24 h. (F) Protein levels of ATGL and HILPDA in wild-type BMDMs treated with vehicle (Ctrl) or LPS for 30 min or 24 h. HSP90 was used as loading control. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.