HILPDA deficiency in myeloid cells affects the inflammatory state in vivo. (A) Hilpda gene expression in isolated splenic macrophages from HilpdaΔLysM and Hilpdafl/fl mice 2, 4, 8, or 24 h after intraperitoneal injection of LPS or 24 h after intraperitoneal injection of saline (Ctrl). (B) Relative fold change and uncorrected P values in plasma proteomic profiles in HilpdaΔLysM and Hilpdafl/fl mice 2, 8, or 24 h after intraperitoneal injection of LPS. Data are represented as mean ± SD. *P < 0.05, ***P < 0.001.