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. 2022 Mar 18;119(12):e2114739119. doi: 10.1073/pnas.2114739119

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Copyright © 2022 the Author(s). Published by PNAS.

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Fig. 7. — Increased production of PGE2 in HILPDA-deficient macrophages drives increased production of IL-6. (A and B) Concentration of IL-6 (A) or PGE2 (B) from Hilpda^ΔLysM and Hilpda^fl/fl BMDMs treated with vehicle (Ctrl) or LPS for 2, 4, 8, or 24 h. (C) Concentration of PGE2 from Hilpda^ΔLysM and Hilpda^fl/fl BMDMs after treatment with LPS or LPS and atglistatin for 24 h. (D) Concentration of IL-6 from Hilpda^ΔLysM and Hilpda^fl/fl BMDMs treated with LPS and/or PGE2 for 4, 8, or 24 h. (E) Concentration of IL-6 from Hilpda^ΔLysM and Hilpda^fl/fl BMDMs treated with LPS and indomethacin or NS-398 for 4, 8, or 24 h. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.