Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 23;12(3):346. doi: 10.3390/biom12030346

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Clinical differentiation between Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and common genetic determinants. In the PD brain, aggregated α-synuclein and Lewy bodies (depicted as red circles) are mainly located in the substantia nigra and the brainstem, which is accompanied by dopaminergic neuronal death, causing typical parkinsonian motor symptoms. In DLB, α-synuclein accumulations and Lewy bodies are predominantly found in cortical brain areas involved in cognitive impairments. PD and DLB both feature individual predisposition genes (PD: LRRK2, Parkin, PINK1 and DJ-1; DLB: APOE4), but also share risk genes that influence the aggregation of α-synuclein (e.g., SNCA and GBA). Created with BioRender.com (last accessed on 1 January 2022).