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. 2022 Mar 14;10(3):670. doi: 10.3390/biomedicines10030670

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Correlations between metabolite activity with that of SQ109 in 4 assays: T. cruzi amastigotes (and the host U2OS cells), T. cruzi epimastigotes, L. donovani promastigotes and T. brucei BSFs. (A) Compound 9, r = 0.90 and p = 0.0373. (B) Compound 12, r = 0.99 and p = 0.0012. (C) Compound 21, r = 0.97 and p = 0.0062. (D) Compound 22, r = 0.93 and p = 0.0219. (E) Compound 23, r = 0.96 and p = 0.0095. (F) Compound 24, r = 0.98 and p = 0.0034. The color codes are T. cruzi epimastigotes = green (●), T. cruzi amastigotes = blue (●), U2OS = red (●), T. brucei BSF = orange (●), L. donovani promastigotes = magenta (●).